A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC3724506 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells.
Tian Yi Y Wu Guoqiang G Xing Jun-Chao JC Tang Jun J Zhang Yi Y Huang Ze-Min ZM Jia Zheng-Cai ZC Zhao Ren R Tian Zhi-Qiang ZQ Wang Shu-Feng SF Chen Xiao-Ling XL Wang Li L Wu Yu-Zhang YZ Ni Bing B
BMC immunology 20120613
<h4>Background</h4>Regulatory T cells (Tregs) are required for proper maintenance of immunological self-tolerance and immune homeostasis. Folate receptor 4 (FR4) is expressed at high levels in transforming growth factor-beta (TGF-β)-induced Tregs and natural Tregs. Moreover, antibody-mediated targeting of FR4 is sufficient to mediate Treg depletion.<h4>Results</h4>In this study, we describe a novel FR4 transcript variant, FR4D3, in which exon 3 is deleted. The mRNA of FR4D3 encodes a FR4 variant ...[more]
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