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Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.

ABSTRACT: We synthesized homologated truncated 4'-thioadenosine analogues 3 in which a methylene (CH(2)) group was inserted in place of the glycosidic bond of a potent and selective A(3) adenosine receptor antagonist 2. The analogues were designed to induce maximum binding interaction in the binding site of the A(3) adenosine receptor. However, all homologated nucleosides were devoid of binding affinity at all subtypes of adenosine receptors, indicating that free rotation through the single bond allowed the compound to adopt an indefinite number of conformations, disrupting the favorable binding interaction essential for receptor recognition.

SUBMITTER: Lee HW

PROVIDER: S-EPMC3724522 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.

Lee Hyuk Woo HW Kim Hea Ok HO Choi Won Jun WJ Choi Sun S Lee Jin Hee JH Park Seul-gi SG Yoo Lena L Jacobson Kenneth A KA Jeong Lak Shin LS

Bioorganic & medicinal chemistry 20100814 19

We synthesized homologated truncated 4'-thioadenosine analogues 3 in which a methylene (CH(2)) group was inserted in place of the glycosidic bond of a potent and selective A(3) adenosine receptor antagonist 2. The analogues were designed to induce maximum binding interaction in the binding site of the A(3) adenosine receptor. However, all homologated nucleosides were devoid of binding affinity at all subtypes of adenosine receptors, indicating that free rotation through the single bond allowed t ...[more]

PMID: 20826090

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