The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.
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ABSTRACT:
SUBMITTER: Seidah NG
PROVIDER: S-EPMC3724608 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.
Seidah Nabil G NG Sadr Mohamad S MS Chrétien Michel M Mbikay Majambu M
The Journal of biological chemistry 20130617 30
The secretory proprotein convertase (PC) family comprises nine members: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9. The first seven PCs cleave their substrates at single or paired basic residues, and SKI-1/S1P cleaves its substrates at non-basic residues in the Golgi. PCSK9 cleaves itself once, and the secreted inactive protease escorts specific receptors for lysosomal degradation. It regulates the levels of circulating LDL cholesterol and is considered a major therapeutic t ...[more]
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