Ontology highlight
ABSTRACT:
SUBMITTER: Cao LS
PROVIDER: S-EPMC3724675 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cao Lu-Sha LS Wang Jue J Chen Yuling Y Deng Haiteng H Wang Zhi-Xin ZX Wu Jia-Wei JW
PloS one 20130726 7
MELK (maternal embryonic leucine zipper kinase), which is a member of the AMPK (AMP-activated protein kinase)-related kinase family, plays important roles in diverse cellular processes and has become a promising drug target for certain cancers. However, the regulatory mechanism of MELK remains elusive. Here, we report the crystal structure of a fragment of human MELK that contains the kinase domain and ubiquitin-associated (UBA) domain. The UBA domain tightly binds to the back of the kinase doma ...[more]