Ontology highlight
ABSTRACT:
SUBMITTER: Bhakta NR
PROVIDER: S-EPMC3724712 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Bhakta Nirav R NR Solberg Owen D OD Nguyen Christine P CP Nguyen Cindy N CN Arron Joseph R JR Fahy John V JV Woodruff Prescott G PG
Clinical and translational allergy 20130717 1
<h4>Background</h4>Using microarray profiling of airway epithelial cells, we previously identified a Th2-high molecular phenotype of asthma based on expression of periostin, CLCA1 and serpinB2 and characterized by specific inflammatory, remodeling, and treatment response features. The goal of the current study was to develop a qPCR-based assay of Th2 inflammation to overcome the limitations of microarray-based methods.<h4>Methods</h4>Airway epithelial brushings were obtained by bronchoscopy from ...[more]