Ontology highlight
ABSTRACT:
SUBMITTER: Nessler J
PROVIDER: S-EPMC3724887 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nessler Jasmin J Bénardais Karelle K Gudi Viktoria V Hoffmann Andrea A Salinas Tejedor Laura L Janßen Stefanie S Prajeeth Chittappen Kandiyil CK Baumgärtner Wolfgang W Kavelaars Annemieke A Heijnen Cobi J CJ van Velthoven Cindy C Hansmann Florian F Skripuletz Thomas T Stangel Martin M
PloS one 20130726 7
For the treatment of patients with multiple sclerosis there are no regenerative approaches to enhance remyelination. Mesenchymal stem cells (MSC) have been proposed to exert such regenerative functions. Intravenous administration of human MSC reduced the clinical severity of experimental autoimmune encephalomyelitis (EAE), an animal model mimicking some aspects of multiple sclerosis. However, it is not clear if this effect was achieved by systemic immunomodulation or if there is an active neuror ...[more]