Ontology highlight
ABSTRACT:
SUBMITTER: Ye L
PROVIDER: S-EPMC3725077 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Ye Li L Wu Jun J Cohen Paul P Kazak Lawrence L Khandekar Melin J MJ Jedrychowski Mark P MP Zeng Xing X Gygi Steven P SP Spiegelman Bruce M BM
Proceedings of the National Academy of Sciences of the United States of America 20130701 30
Classic brown fat and inducible beige fat both dissipate chemical energy in the form of heat through the actions of mitochondrial uncoupling protein 1. This nonshivering thermogenesis is crucial for mammals as a defense against cold and obesity/diabetes. Cold is known to act indirectly through the sympathetic nervous systems and β-adrenergic signaling, but here we report that cool temperature (27-33 °C) can directly activate a thermogenic gene program in adipocytes in a cell-autonomous manner. W ...[more]