Ontology highlight
ABSTRACT:
SUBMITTER: Chislock EM
PROVIDER: S-EPMC3725093 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Chislock Elizabeth M EM Ring Colleen C Pendergast Ann Marie AM
Proceedings of the National Academy of Sciences of the United States of America 20130709 30
Endothelial dysfunction is associated with diverse cardiovascular pathologies. Here, we show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelial function and the regulation of angiogenic factor pathways important for vascular homeostasis. Endothelial Abl deletion in Arg-null mice led to late-stage embryonic and perinatal lethality, with mutant mice displaying focal loss of vasculature and tissue necrosis. Loss of Abl kinases led to increased endothel ...[more]