Evolutionary diversification of the multimeric states of proteins.
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ABSTRACT:
SUBMITTER: Lynch M
PROVIDER: S-EPMC3725103 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Evolutionary diversification of the multimeric states of proteins.
Proceedings of the National Academy of Sciences of the United States of America 20130708 30
One of the most striking features of proteins is their common assembly into multimeric structures, usually homomers with even numbers of subunits all derived from the same genetic locus. However, although substantial structural variation for orthologous proteins exists within and among major phylogenetic lineages, in striking contrast to patterns of gene structure and genome organization, there appears to be no correlation between the level of protein structural complexity and organismal complex ...[more]
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