Ontology highlight
ABSTRACT:
SUBMITTER: Wan M
PROVIDER: S-EPMC3725134 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cell metabolism 20130701 1
Insulin rapidly suppresses hepatic glucose production and slowly decreases expression of genes encoding gluconeogenic proteins. In this study, we show that an immediate effect of insulin is to redirect newly synthesized glucose-6-phosphate to glycogen without changing the rate of gluconeogenesis. This process requires hepatic Akt2, as revealed by blunted insulin-mediated suppression of glycogenolysis in the perfused mouse liver, elevated hepatic glucose production during a euglycemic-hyperinsuli ...[more]