Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC3725147 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chen Yao Y Zhang Jinsong J Hwang Kwan-Ki KK Bouton-Verville Hilary H Xia Shi-Mao SM Newman Amanda A Ouyang Ying-Bin YB Haynes Barton F BF Verkoczy Laurent L
Journal of immunology (Baltimore, Md. : 1950) 20130703 3
Developing an HIV-1 vaccine has been hampered by the inability of immunogens to induce broadly neutralizing Abs (BnAbs) that protect against infection. Previously, we used knockin (KI) mice expressing a prototypical gp41-specific BnAb, 2F5, to demonstrate that immunological tolerance triggered by self-reactivity of the 2F5 H chain impedes BnAb induction. In this study, we generate KI models expressing H chains from two other HIV-1 Abs, 4E10 (another self-/polyreactive, anti-gp41 BnAb) and 48d (a ...[more]