Peroxisome proliferator activated receptor gamma gene variants influence susceptibility and insulin related traits in Indian women with polycystic ovary syndrome.

ABSTRACT: PURPOSE: Peroxisome proliferator activated receptor gamma (PPAR?), a transcription factor involved in glucose and lipid metabolism is one of the candidate genes associated with polycystic ovary syndrome (PCOS). We investigated individual and combined associations of Pro12Ala and His447His polymorphisms of PPAR? with PCOS susceptibility and its related traits (hyperinsulinemia, hyperandrogenemia and lipid parameters) in Indian women. METHOD: Genotyping of PPAR? polymorphisms in this case-control study was performed in PCOS (n?=?450) and age-matched controls (n?=?300) by direct sequencing. Clinical, anthropometric, hormonal and metabolic parameters were estimated in 275 women with PCOS and 169 controls. Chi-square test was used to compare the categorical data while regression analysis was used to evaluate association of genotypes with PCOS as well as its related phenotypes. RESULTS: The frequencies of CC and CG?+?GG genotypes of Pro12Ala (?²?=?15.3, p?

SUBMITTER: Shaikh N 

PROVIDER: S-EPMC3725223 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature