Extracting global system dynamics of corticosteroid genomic effects in rat liver.
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ABSTRACT:
SUBMITTER: Yang E
PROVIDER: S-EPMC3725546 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Extracting global system dynamics of corticosteroid genomic effects in rat liver.
Yang E E Almon R R RR Dubois D C DC Jusko W J WJ Androulakis I P IP
The Journal of pharmacology and experimental therapeutics 20071217 3
One of the challenges in constructing biological models involves resolving meaningful data patterns from which the mathematical models will be generated. For models that describe the change of mRNA in response to drug administration, questions exist whether the correct genes have been selected given the myriad transcriptional effects that may occur. Oftentimes, different algorithms will select or cluster different groups of genes from the same data set. A new approach was developed that focuses ...[more]
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