Cytotoxicity and pharmacogenomics of medicinal plants from traditional korean medicine.

ABSTRACT: Aim. The present study was designed to investigate the cytotoxicity of a panel of 280 Korean medicinal plants belonging to 73 families and 198 species against human CCRF-CEM leukemia cells. Selected phytochemicals were investigated in more detail for their mode of action. Methods. The resazurin assay was used to determine cytotoxicity of the plant extracts. Microarray-based mRNA expression profiling, COMPARE, and hierarchical cluster analyses were applied to identify which genes correlate with sensitivity or resistance to selected phytochemicals of the Korean plants. Results. The results of the resazurin assay showed that cytotoxicity extracts tested at 10  μ g/mL from 13 samples inhibited proliferation more than 50% (IC50 < 10  μ g/mL) and the most active plants are Sedum middendorffianum

SUBMITTER: Kuete V 

PROVIDER: S-EPMC3725712 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature