Ontology highlight
ABSTRACT:
SUBMITTER: Forbes CR
PROVIDER: S-EPMC3725732 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Forbes Christina R CR Zondlo Neal J NJ
Organic letters 20120106 2
Aryl thiolates have unique reactive, redox, electronic, and spectroscopic properties. A practical approach to synthesize peptides containing thiophenylalanine has been developed via a novel Cu(I)-mediated cross-coupling reaction between thiolacetic acid and iodophenylalanine-containing peptides in the solid phase. This approach is compatible with all canonical proteinogenic functional groups, providing general access to aryl thiolates in peptides. Peptides containing thiophenylalanine (pK(a) 6.4 ...[more]