Global hormone profiling of murine placenta reveals Secretin expression.
Ontology highlight
ABSTRACT: Objective
To elucidate and categorize the murine placental hormones expressed across gestation, including the expression of hormones with previously undescribed roles.Study design
Expression levels of all genes with known or predicted hormone activity expressed in two separate tissues, the placenta and maternal decidua, were assessed across a timecourse spanning the full lifetime of the placenta. Novel expression patterns were confirmed by in situ hybridization and protein level measurements.Results
A combination of temporal and spatial information defines five groups that can accurately predict the patterns of uncharacterized hormones. Our analysis identified Secretin, a novel placental hormone that is expressed specifically by the trophoblast at levels many times greater than in any other tissue.Conclusions
The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy.
SUBMITTER: Knox K
PROVIDER: S-EPMC3725973 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Global hormone profiling of murine placenta reveals Secretin expression.
Knox K K Leuenberger D D Penn A A AA Baker J C JC
Placenta 20110925 11
<h4>Objective</h4>To elucidate and categorize the murine placental hormones expressed across gestation, including the expression of hormones with previously undescribed roles.<h4>Study design</h4>Expression levels of all genes with known or predicted hormone activity expressed in two separate tissues, the placenta and maternal decidua, were assessed across a timecourse spanning the full lifetime of the placenta. Novel expression patterns were confirmed by in situ hybridization and protein level ...[more]
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