Ontology highlight
ABSTRACT:
SUBMITTER: Williams-Karnesky RL
PROVIDER: S-EPMC3726154 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Williams-Karnesky Rebecca L RL Sandau Ursula S US Lusardi Theresa A TA Lytle Nikki K NK Farrell Joseph M JM Pritchard Eleanor M EM Kaplan David L DL Boison Detlev D
The Journal of clinical investigation 20130725 8
Epigenetic modifications, including changes in DNA methylation, lead to altered gene expression and thus may underlie epileptogenesis via induction of permanent changes in neuronal excitability. Therapies that could inhibit or reverse these changes may be highly effective in halting disease progression. Here we identify an epigenetic function of the brain's endogenous anticonvulsant adenosine, showing that this compound induces hypomethylation of DNA via biochemical interference with the transme ...[more]