Ontology highlight
ABSTRACT:
SUBMITTER: Dabir DV
PROVIDER: S-EPMC3726224 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Dabir Deepa V DV Hasson Samuel A SA Setoguchi Kiyoko K Johnson Meghan E ME Wongkongkathep Piriya P Douglas Colin J CJ Zimmerman Johannes J Damoiseaux Robert R Teitell Michael A MA Koehler Carla M CM
Developmental cell 20130401 1
The mitochondrial disulfide relay system of Mia40 and Erv1/ALR facilitates import of the small translocase of the inner membrane (Tim) proteins and cysteine-rich proteins. A chemical screen identified small molecules that inhibit Erv1 oxidase activity, thereby facilitating dissection of the disulfide relay system in yeast and vertebrate mitochondria. One molecule, mitochondrial protein import blockers from the Carla Koehler laboratory (MitoBloCK-6), attenuated the import of Erv1 substrates into ...[more]