Dataset Information

The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular degeneration: a cross-sectional study.

ABSTRACT:

Objectives

To evaluate potential differences in plasma 25-hydroxyvitamin in subtypes of age-related macular degeneration (AMD), and in patients in Clinical Age-Related Maculopathy Staging (CARMS) group 5 with or without subretinal fibrosis.

Methods

This single-center cross-sectional study included 178 participants during a period of 20 months. Ninety-five patients belonged to CARMS 5; twelve belonged to CARMS 4; twenty-two belonged to CARMS 2 or 3; and 49 individuals did not have AMD (CARMS 1). Following a structured interview, a detailed bilateral retinal examination was performed and participants were allocated to their respective subgroups in accordance with the Clinical Age-Related Maculopathy Staging system. Plasma 25-hydroxyvitamin D2 and D3 were analyzed using liquid chromatography-tandem mass spectrometry. Genomic DNA was extracted from leukocytes and genotyped for single nucleotide polymorphisms (SNPs) in the vitamin D metabolism. Differences in plasma 25-hydroxyvitamin D were determined in the subgroups as well as between patients in CARMS 5 with or without subretinal fibrosis.

Results

Plasma 25-hydroxyvitamin D was comparable in patients across CARMS groups 1 to 5 (p?=?0.83). In CARMS 5, the presence of subretinal fibrosis was associated with significantly lower concentrations of 25-hydroxyvitamin D as compared to the absence of subretinal fibrosis (47.2 versus 75.6 nmol/L, p<0.001). Patients in CARMS 5 with subretinal fibrosis were more likely to have insufficient levels of 25-hydroxyvitamin D compared to patients without subretinal fibrosis (p?=?0.006). No association was found between the SNPs rs10877012, rs2228570, rs4588, or rs7041 and AMD subgroups or plasma 25-hydroxyvitamin levels.

Conclusions

This study suggests that the presence of subretinal fibrosis in patients belonging to CARMS 5 may be associated with a poor vitamin D status. Our observations warrant further investigation into the role of vitamin D in the development of subretinal fibrosis.

SUBMITTER: Singh A

PROVIDER: S-EPMC3726594 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular degeneration: a cross-sectional study.

Singh Amardeep A Falk Mads Krüger MK Subhi Yousif Y Sørensen Torben Lykke TL

PloS one 20130729 7

<h4>Objectives</h4>To evaluate potential differences in plasma 25-hydroxyvitamin in subtypes of age-related macular degeneration (AMD), and in patients in Clinical Age-Related Maculopathy Staging (CARMS) group 5 with or without subretinal fibrosis.<h4>Methods</h4>This single-center cross-sectional study included 178 participants during a period of 20 months. Ninety-five patients belonged to CARMS 5; twelve belonged to CARMS 4; twenty-two belonged to CARMS 2 or 3; and 49 individuals did not have ...[more]

PMID: 23923033

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Dataset Information

The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular degeneration: a cross-sectional study.

Objectives

Methods

Results

Conclusions

Publications

The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular degeneration: a cross-sectional study.

Similar Datasets

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