Ontology highlight
ABSTRACT:
SUBMITTER: Kalivoda EJ
PROVIDER: S-EPMC3726613 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kalivoda Eric J EJ Brothers Kimberly M KM Stella Nicholas A NA Schmitt Matthew J MJ Shanks Robert M Q RM
PloS one 20130729 7
Biofilm-related infections are a major contributor to human disease, and the capacity for surface attachment and biofilm formation are key attributes for the pathogenesis of microbes. Serratia marcescens type I fimbriae-dependent biofilms are coordinated by the adenylate cyclase, CyaA, and the cyclic 3',5'-adenosine monophosphate (cAMP)-cAMP receptor protein (CRP) complex. This study uses S. marcescens as a model system to test the role of cAMP-phosphodiesterase activity in controlling biofilm f ...[more]