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Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011.

ABSTRACT: Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.

SUBMITTER: Thoa le PK

PROVIDER: S-EPMC3726754 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011.

Thoa Le Phan Kim le PK Chiang Pai-Shan PS Khanh Truong Huu TH Luo Shu-Ting ST Dan Tran Ngoc Hanh TN Wang Ya-Fang YF Thuong Tang Chi TC Chung Wan-Yu WY Hung Nguyen Thanh NT Wang Jen-Ren JR Nhan Le Nguyen Thanh le NT Thinh Le Quoc le Q Su Ih-Jen IJ Dung Than Duc TD Lee Min-Shi MS

PloS one 20130729 7

Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formul ...[more]

PMID: 23922846

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