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ABSTRACT:
SUBMITTER: Huyghe JR
PROVIDER: S-EPMC3727235 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20121223 2
Insulin secretion has a crucial role in glucose homeostasis, and failure to secrete sufficient insulin is a hallmark of type 2 diabetes. Genome-wide association studies (GWAS) have identified loci contributing to insulin processing and secretion; however, a substantial fraction of the genetic contribution remains undefined. To examine low-frequency (minor allele frequency (MAF) 0.5-5%) and rare (MAF < 0.5%) nonsynonymous variants, we analyzed exome array data in 8,229 nondiabetic Finnish males u ...[more]