Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3727304 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Wang Ying Y Matthewman Cristina C Han Lu L Miller Tyne T Miller David M DM Bianchi Laura L
The Journal of general physiology 20130801 2
Ion channels of the DEG/ENaC family can induce neurodegeneration under conditions in which they become hyperactivated. The Caenorhabditis elegans DEG/ENaC channel MEC-4(d) encodes a mutant channel with a substitution in the pore domain that causes swelling and death of the six touch neurons in which it is expressed. Dominant mutations in the C. elegans DEG/ENaC channel subunit UNC-8 result in uncoordinated movement. Here we show that this unc-8 movement defect is correlated with the selective de ...[more]