Ontology highlight
ABSTRACT:
SUBMITTER: Bromley D
PROVIDER: S-EPMC3727652 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Bromley Dennis D Anderson Peter C PC Daggett Valerie V
Biochemistry 20130610 24
The α-tocopherol transfer protein (α-TTP) is a liver protein that transfers α-tocopherol (vitamin E) to very-low-density lipoproteins (VLDLs). These VLDLs are then circulated throughout the body to maintain blood α-tocopherol levels. Mutations to the α-TTP gene are associated with ataxia with vitamin E deficiency, a disease characterized by peripheral nerve degeneration. In this study, molecular dynamics simulations of the E141K and R59W disease-associated mutants were performed. The mutants dis ...[more]