Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC3727912 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Wang Wang W Barnabei Matthew S MS Asp Michelle L ML Heinis Frazer I FI Arden Erik E Davis Jennifer J Braunlin Elizabeth E Li Qi Q Davis Jonathan P JP Potter James D JD Metzger Joseph M JM
Nature medicine 20130210 3
EF-hand proteins are ubiquitous in cell signaling. Parvalbumin (Parv), the archetypal EF-hand protein, is a high-affinity Ca(2+) buffer in many biological systems. Given the centrality of Ca(2+) signaling in health and disease, EF-hand motifs designed to have new biological activities may have widespread utility. Here, an EF-hand motif substitution that had been presumed to destroy EF-hand function, that of glutamine for glutamate at position 12 of the second cation binding loop domain of Parv ( ...[more]