Ontology highlight
ABSTRACT:
SUBMITTER: Panosa C
PROVIDER: S-EPMC3728333 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Panosa Clara C Tebar Francesc F Ferrer-Batallé Montserrat M Fonge Humphrey H Seno Masaharu M Reilly Raymond M RM Massaguer Anna A De Llorens Rafael R
PloS one 20130730 7
The members of the epidermal growth factor (EGF)/ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that inactivate the ErbB receptors through novel strategies is an important goal on cancer research. In this study we have developed a shorter form of human EGF (EGFt) with a truncated C-terminal as a novel EGFR inhibitor. EGFt was designed based on the superimposition of the three-dimen ...[more]