Ontology highlight
ABSTRACT:
SUBMITTER: Sasai N
PROVIDER: S-EPMC3728336 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sasai Nobuhiro N Saitoh Noriko N Saitoh Hisato H Nakao Mitsuyoshi M
PloS one 20130730 7
Cellular senescence is post-mitotic or oncogene-induced events combined with nuclear remodeling. MCAF1 (also known as hAM or ATF7IP), a transcriptional cofactor that is overexpressed in various cancers, functions in gene activation or repression, depending on interacting partners. In this study, we found that MCAF1 localizes to PML nuclear bodies in human fibroblasts and non-cancerous cells. Interestingly, depletion of MCAF1 in fibroblasts induced premature senescence that was characterized by c ...[more]