Ontology highlight
ABSTRACT:
SUBMITTER: Fenne IS
PROVIDER: S-EPMC3728357 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Fenne Ingvild S IS Helland Thomas T Flågeng Marianne H MH Dankel Simon N SN Mellgren Gunnar G Sagen Jørn V JV
PloS one 20130730 7
The p160/Steroid Receptor Coactivators SRC-1, SRC-2/GRIP1, and SRC-3/AIB1 are important regulators of Estrogen Receptor alpha (ERα) activity. However, whereas the functions of SRC-1 and SRC-3 in breast tumourigenesis have been extensively studied, little is known about the role of SRC-2. Previously, we reported that activation of the cAMP-dependent protein kinase, PKA, facilitates ubiquitination and proteasomal degradation of SRC-2 which in turn leads to inhibition of SRC-2-coactivation of ERα a ...[more]