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Three-dimensional biomimetic patterning in hydrogels to guide cellular organization.

ABSTRACT: An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale.

SUBMITTER: Culver JC

PROVIDER: S-EPMC3728891 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Three-dimensional biomimetic patterning in hydrogels to guide cellular organization.

Culver James C JC Hoffmann Joseph C JC Poché Ross A RA Slater John H JH West Jennifer L JL Dickinson Mary E ME

Advanced materials (Deerfield Beach, Fla.) 20120330 17

An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at ...[more]

PMID: 22467256

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