Ontology highlight
ABSTRACT:
SUBMITTER: Raifman O
PROVIDER: S-EPMC3729217 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Raifman Or O Kolusheva Sofiya S El Kazzouli Said S Sigano Dina M DM Kedei Noemi N Lewin Nancy E NE Lopez-Nicolas Ruben R Ortiz-Espin Ana A Gomez-Fernandez Juan C JC Blumberg Peter M PM Marquez Victor E VE Corbalan-Garcia Senena S Jelinek Raz R
Chembiochem : a European journal of chemical biology 20100901 14
Synthetic diacylglycerol-lactones (DAG-lactones) are effective modulators of critical cellular signaling pathways, downstream of the lipophilic second messenger diacylglycerol, that activate a host of protein kinase C (PKC) isozymes and other nonkinase proteins that share similar C1 membrane-targeting domains with PKC. A fundamental determinant of the biological activity of these amphiphilic molecules is the nature of their interactions with cellular membranes. This study examines the biological ...[more]