Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex.
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ABSTRACT:
SUBMITTER: Mohandessi S
PROVIDER: S-EPMC3729426 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex.
Mohandessi Shabnam S Rajendran Megha M Magda Darren D Miller Lawrence W LW
Chemistry (Weinheim an der Bergstrasse, Germany) 20120717 35
Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates. ...[more]
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