Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC3729559 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Li Zhengyue Z Guo Yilian Y Lu Yu Y Li Jianzhong J Jin Zhanguo Z Li Hongbo H Lu Yanping Y Dai Pu P Han Dongyi D Cheng Jing J Yuan Huijun H
PloS one 20130731 7
Tectorial membrane, an extracellular matrix of the cochlea, plays a crucial role in the transmission of sound to the sensory hair cells. Alpha-tectorin is the most important noncollagenous component of the tectorial membrane and the otolith membrane in the maculae of the vestibular system. Defects in TECTA, the gene encodes alpha-tectorin, are cause of both dominant (DFNA8/12) and recessive (DFNB21) forms of deafness. Here, we report a three-generation Chinese family characterized by prelingual ...[more]