Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels.
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ABSTRACT:
SUBMITTER: Gonzalez-Toro DC
PROVIDER: S-EPMC3729588 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels.
González-Toro Daniella C DC Ryu Ja-Hyoung JH Chacko Reuben T RT Zhuang Jiaming J Thayumanavan S S
Journal of the American Chemical Society 20120411 16
Supramolecular nanoassemblies, which are capable of binding and delivering either lipophilic small molecules or hydrophilic molecules, are of great interest. Concurrently binding and delivering this combination of molecules is cumbersome, because of the opposing supramolecular host requirements. We describe the development of a versatile nanoassembly system that is capable of binding and delivering both, a protein and a lipophilic small molecule, simultaneously inside the cells. ...[more]
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