Impaired adult myelination in the prefrontal cortex of socially isolated mice.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC3729624 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Impaired adult myelination in the prefrontal cortex of socially isolated mice.
Liu Jia J Dietz Karen K DeLoyht Jacqueline M JM Pedre Xiomara X Kelkar Dipti D Kaur Jasbir J Vialou Vincent V Lobo Mary Kay MK Dietz David M DM Nestler Eric J EJ Dupree Jeffrey J Casaccia Patrizia P
Nature neuroscience 20121111 12
Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that my ...[more]
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