Unknown

Dataset Information

0

Breast cancer survival in Germany: a population-based high resolution study from Saarland.


ABSTRACT: Population-based survival studies of breast cancer patients are commonly restricted to age- and stage-specific analyses. This study from Germany aimed at extending available population-based survival data on further prognostic cancer characteristics such as tumor grade, hormone receptor status and human epidermal growth factor receptor type 2 (HER2/neu) expression. Data from the population-based Saarland Cancer Registry including female patients diagnosed with invasive breast cancer between 2000 and 2009 were included. Period analysis methodology and regression modelling were used to obtain estimates of 5-year relative survival and tumor related excess risks in 2005-2009. Overall age standardized 5-year relative survival was 83%. In addition to age and stage, tumor grade and hormone receptor status were independent predictors of 5-year relative survival. Detailed analyses by age, stage, morphology, tumor grade, hormone receptor status and HER2/neu expression consistently revealed lower survival of patients with high grade, hormone receptor negative or HER2/neu positive cancers and patients aged 70 years or older. This high resolution study extends available population-based survival data of breast cancer patients. Particular efforts should be made to overcome the persisting large survival deficits, which were observed for elderly patients in all clinical subgroups.

SUBMITTER: Holleczek B 

PROVIDER: S-EPMC3729832 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Breast cancer survival in Germany: a population-based high resolution study from Saarland.

Holleczek Bernd B   Jansen Lina L   Brenner Hermann H  

PloS one 20130731 7


Population-based survival studies of breast cancer patients are commonly restricted to age- and stage-specific analyses. This study from Germany aimed at extending available population-based survival data on further prognostic cancer characteristics such as tumor grade, hormone receptor status and human epidermal growth factor receptor type 2 (HER2/neu) expression. Data from the population-based Saarland Cancer Registry including female patients diagnosed with invasive breast cancer between 2000  ...[more]

Similar Datasets

| S-EPMC4706735 | biostudies-literature
| S-EPMC7558406 | biostudies-literature
| S-EPMC4432376 | biostudies-literature
| S-EPMC3702575 | biostudies-other
| S-EPMC9015991 | biostudies-literature
| S-EPMC5419505 | biostudies-literature
| S-EPMC7326086 | biostudies-literature
| S-EPMC6812853 | biostudies-literature
| S-EPMC4119969 | biostudies-literature
| S-EPMC7490663 | biostudies-literature