Ontology highlight
ABSTRACT:
SUBMITTER: Carpenter RD
PROVIDER: S-EPMC3729919 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
European journal of organic chemistry 20110301 7
Triazacryptand (TAC)-based fluorescent K<sup>+</sup> sensors have broad biomedical utility, yet their advancement has been hindered because of their challenging synthesis. Herein, an efficient synthesis is reported that delivers a didesmethyl tri-azacryptand (ddTAC) K<sup>+</sup> sensor in twofold fewer steps and ninefold higher overall yield than the original TAC synthesis. Our synthesis utilizes a C-O dianionic oxidative macrocyclization and reports new examples of aminoarylations and a microw ...[more]