Ontology highlight
ABSTRACT:
SUBMITTER: Murima P
PROVIDER: S-EPMC3729944 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Murima Paul P de Sessions Paola Florez PF Lim Vivian V Naim Ahmad Nazri Mohamed AN Bifani Pablo P Boshoff Helena I M HI Sambandamurthy Vasan K VK Dick Thomas T Hibberd Martin L ML Schreiber Mark M Rao Srinivasa P S SP
PloS one 20130731 7
Most candidate anti-bacterials are identified on the basis of their whole cell anti-bacterial activity. A critical bottleneck in the early discovery of novel anti-bacterials is tracking the structure activity relationship (SAR) of the novel compounds synthesized during the hit to lead and lead optimization stage. It is often very difficult for medicinal chemists to visualize if the novel compounds synthesized for understanding SAR of a particular scaffold have similar molecular mechanism of acti ...[more]