Ontology highlight
ABSTRACT:
SUBMITTER: Friedman JA
PROVIDER: S-EPMC3730018 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Friedman Jay A JA Wise Stephanie C SC Hu Michael M Gouveia Chris C Vander Broek Robert R Freudlsperger Christian C Kannabiran Vishnu R VR Arun Pattatheyil P Mitchell James B JB Chen Zhong Z Van Waes Carter C
Translational oncology 20130801 4
Heat shock protein 90 (HSP90) is a chaperone protein that stabilizes proteins involved in oncogenic and therapeutic resistance pathways of epithelial cancers, including head and neck squamous cell carcinomas (HNSCCs). Here, we characterized the molecular, cellular, and preclinical activity of HSP90 inhibitor SNX5422/2112 in HNSCC overexpressing HSP90. SNX2112 inhibited proliferation, induced G2/M block, and enhanced cytotoxicity, chemosensitivity, and radiosensitivity between 25 and 250 nM in vi ...[more]