Insulin degludec once-daily in type 2 diabetes: simple or step-wise titration (BEGIN: once simple use).

ABSTRACT:

Introduction

Insulin degludec (IDeg) is a new basal insulin in development with a flat, ultra-long action profile that may permit dosing using a simplified titration algorithm with less frequent self-measured blood glucose (SMBG) measurements and more simplified titration steps than currently available basal insulins.

Methods

This 26-week, multi-center, open-label, randomized, treat-to-target study compared the efficacy and safety of IDeg administered once-daily in combination with metformin in insulin-naïve subjects with type 2 diabetes using two different patient-driven titration algorithms: a "Simple" algorithm, with dose adjustments based on one pre-breakfast SMBG measurement (n = 111) versus a "Step-wise" algorithm, with adjustments based on three consecutive pre-breakf

SUBMITTER: Philis-Tsimikas A 

PROVIDER: S-EPMC3730088 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature