Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.
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ABSTRACT:
SUBMITTER: Smith JD
PROVIDER: S-EPMC3730239 | biostudies-literature | 1995 Jul
REPOSITORIES: biostudies-literature
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Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.
Smith J D JD Chitnis C E CE Craig A G AG Roberts D J DJ Hudson-Taylor D E DE Peterson D S DS Pinches R R Newbold C I CI Miller L H LH
Cell 19950701 1
Plasmodium falciparum expresses on the host erythrocyte surface clonally variant antigens and ligands that mediate adherence to endothelial receptors. Both are central to pathogenesis, since they allow chronicity of infection and lead to concentration of infected erythrocytes in cerebral vessels. Here we show that expression of variant antigenic determinants is correlated with expression of individual members of a large, multigene family named var. Each var gene contains copies of a motif that h ...[more]
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