Nitric oxide modulation of low-frequency oscillations in cortical vessels in FHM--a NIRS study.

ABSTRACT:

Background

The pathophysiological alterations in patients with familial hemiplegic migraine (FHM) are not yet fully known. The headache characteristics in patients with FHM mutations have been examined in a series of glyceryl trinitrate (GTN) provocation studies in FHM patients, but the cortical vascular response to GTN in FHM patients has never been investigated before.

Objective

To investigate changes in spontaneous low-frequency oscillations (LFO) of cortical vessels in response to the nitric oxide donor GTN by near-infrared spectroscopy in FHM patients.

Methods

Twenty-three FHM patients without known mutations and 9 healthy controls received a continuous intravenous infusion of GTN 0.5 µg/kg/minute over 20 minutes. Using near-infrared spectroscopy, we recorded oxy

SUBMITTER: Schytz HW 

PROVIDER: S-EPMC3730264 | biostudies-literature | 2012 Jul-Aug

REPOSITORIES: biostudies-literature