Pharmacogenetic biomarkers for the prediction of response to antiangiogenic treatment.
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ABSTRACT:
SUBMITTER: Schneider BP
PROVIDER: S-EPMC3730288 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Pharmacogenetic biomarkers for the prediction of response to antiangiogenic treatment.
Schneider Bryan P BP Shen Fei F Miller Kathy D KD
The Lancet. Oncology 20121001 10
Antiangiogenic treatments have shown activity across multiple tumour types and in various settings. Despite having been approved on the basis of efficacy, the therapeutic index varies substantially in different settings for many of these agents. A major limitation is the current inability to personalise treatment a priori according to findings on measurement of a predictive biomarker. The roles of germline single-nucleotide polymorphisms have been investigated as potential biomarkers for antiang ...[more]
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