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Novel systemic therapies in advanced liposarcoma: a review of recent clinical trial results.

ABSTRACT: Liposarcoma is one of the most common adult soft tissue sarcomas and consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging.

SUBMITTER: Tseng WW

PROVIDER: S-EPMC3730323 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Novel systemic therapies in advanced liposarcoma: a review of recent clinical trial results.

Tseng William W WW Somaiah Neeta N Lazar Alexander J AJ Lev Dina C DC Pollock Raphael E RE

Cancers 20130510 2

Liposarcoma is one of the most common adult soft tissue sarcomas and consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of seve ...[more]

PMID: 24216990

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