Evolutionary rate heterogeneity of core and attachment proteins in yeast protein complexes.

ABSTRACT: In general, proteins do not work alone; they form macromolecular complexes to play fundamental roles in diverse cellular functions. On the basis of their iterative clustering procedure and frequency of occurrence in the macromolecular complexes, the protein subunits have been categorized as core and attachment. Core protein subunits are the main functional elements, whereas attachment proteins act as modifiers or activators in protein complexes. In this article, using the current data set of yeast protein complexes, we found that core proteins are evolving at a faster rate than attachment proteins in spite of their functional importance. Interestingly, our investigation revealed that attachment proteins are present in a higher number of macromolecular complexes than core proteins. We also

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC3730348 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature