Ontology highlight
ABSTRACT:
SUBMITTER: Selman C
PROVIDER: S-EPMC3730656 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Selman Colin C McLaren Jane S JS Collins Andrew R AR Duthie Garry G GG Speakman John R JR
Biology letters 20130703 4
While oxidative damage owing to reactive oxygen species (ROS) often increases with advancing age and is associated with many age-related diseases, its causative role in ageing is controversial. In particular, studies that have attempted to modulate ROS-induced damage, either upwards or downwards, using antioxidant or genetic approaches, generally do not show a predictable effect on lifespan. Here, we investigated whether dietary supplementation with either vitamin E (α-tocopherol) or vitamin C ( ...[more]