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2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

ABSTRACT: Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

SUBMITTER: Raffa D

PROVIDER: S-EPMC3731050 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

Raffa Demetrio D Maggio Benedetta B Raimondi Maria Valeria MV Cusimano Maria Grazia MG Amico Giandomenico G Carollo Anna A Conaldi Pier Giulio PG Bai Ruoli R Hamel Ernest E Daidone Giuseppe G

European journal of medicinal chemistry 20130514

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells). ...[more]

PMID: 23747810

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