Ontology highlight
ABSTRACT:
SUBMITTER: Caixeta FV
PROVIDER: S-EPMC3731648 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Caixeta Fábio V FV Cornélio Alianda M AM Scheffer-Teixeira Robson R Ribeiro Sidarta S Tort Adriano B L AB
Scientific reports 20130101
Recent studies show that higher order oscillatory interactions such as cross-frequency coupling are important for brain functions that are impaired in schizophrenia, including perception, attention and memory. Here we investigated the dynamics of oscillatory coupling in the hippocampus of awake rats upon NMDA receptor blockade by ketamine, a pharmacological model of schizophrenia. Ketamine (25, 50 and 75 mg/kg i.p.) increased gamma and high-frequency oscillations (HFO) in all depths of the CA1-d ...[more]