Ontology highlight
ABSTRACT:
SUBMITTER: An L
PROVIDER: S-EPMC3731650 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
An Lei L Jia Wei W Yu Yang Y Zou Ning N Liang Li L Zhao Yanling Y Fan Yihui Y Cheng Jin J Shi Zhongcheng Z Xu Gufeng G Li Grace G Yang Jianhua J Zhang Hong H
Scientific reports 20130101
The RAF kinase family is essential in mediating signal transduction from RAS to ERK. BRAF constitutively active mutations correlate with human cancer development. However, the precise molecular regulation of BRAF activation is not fully understood. Here we report that BRAF is modified by Lys63-linked polyubiquitination at lysine 578 within its kinase domain once it is activated by gain of constitutively active mutation or epidermal growth factor (EGF) stimulation. Substitution of BRAF lysine 578 ...[more]