Ontology highlight
ABSTRACT:
SUBMITTER: Moberly SP
PROVIDER: S-EPMC3731771 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Moberly Steven P SP Mather Kieren J KJ Berwick Zachary C ZC Owen Meredith K MK Goodwill Adam G AG Casalini Eli D ED Hutchins Gary D GD Green Mark A MA Ng Yen Y Considine Robert V RV Perry Kevin M KM Chisholm Robin L RL Tune Johnathan D JD
Basic research in cardiology 20130614 4
Glucagon-like peptide 1 (GLP-1) has insulin-like effects on myocardial glucose uptake which may contribute to its beneficial effects in the setting of myocardial ischemia. Whether these effects are different in the setting of obesity or type 2 diabetes (T2DM) requires investigation. We examined the cardiometabolic actions of GLP-1 (7-36) in lean and obese/T2DM humans, and in lean and obese Ossabaw swine. GLP-1 significantly augmented myocardial glucose uptake under resting conditions in lean hum ...[more]