Ontology highlight
ABSTRACT:
SUBMITTER: Louis Jeune V
PROVIDER: S-EPMC3732124 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Louis Jeune Vedell V Joergensen Jakob A JA Hajjar Roger J RJ Weber Thomas T
Human gene therapy methods 20130403 2
Adeno-associated virus (AAV)-based vectors are promising tools for gene therapeutic applications, in part because AAVs are nonpathogenic viruses, and vectors derived from them can drive long-term transgene expression without integration of the vector DNA into the host genome. AAVs are not strongly immunogenic, but they can, nonetheless, give rise to both a cellular and humoral immune response. As a result, a significant fraction of potential patients for AAV-based gene therapy harbors pre-existi ...[more]